It really is a bad time for comedies, even though we really could use the comedic relief at the moment. Movie studios are just not putting the money into mid budget films anymore. Mainstream studio comedy has suffered quite a bit. Nobody has really cracked the code since the Apatow/Hangover era. It’s incredibly telling that “Game Night” is considered one of the bigger hit comedies recently and could only scrape $69 million domestically.
Seth Rogen was on a podcast a couple years ago saying how hard it is to get studio comedies made nowadays compared to the 2000s where studios were buying up comedies like crazy because they all tended to turn profits on DVD. Big-budget movies are tailored more and more to a global audience. Comedies don't really translate well overseas, so there is less incentive to make them.
2010's
This is the End, Bridesmaids, Neighbors, 21 Jump Street, MacGruber, Trainwreck, That's My Boy, The Heat, The Sitter, Bad Teacher, Daddy's Home, The House
2000's
Superbad, Step Brothers, The Hangover, Wedding Crashers, Dodgeball, Anchorman, Elf, The 40 Year Old Virgin, Old School, Tropic Thunder, Mean Girls, School of Rock, Meet the Parents, Zoolander, Pineapple Express, Borat, Team America: World Police, Role Models, Bad Santa, Little Miss Sunshine
1990's
Office Space, Dumb and Dumber, Home Alone, Groundhog Day, Happy Gilmore, American Pie, Austin Powers: The Spy Who Shagged Me, Ace Ventura, Tommy Boy, Mrs. Doubtfire, There's Something About Mary, My Cousin Vinny, Billy Madison, The Big Lebowski, The Waterboy, The Mask, South Park, What About Boy? Beavis and Butthead Do America